Novel Integron-Mediated Fosfomycin Resistance GenefosK
نویسندگان
چکیده
منابع مشابه
The ORF1 gene located on the class-1-integron-associated gene cassette actually represents a novel fosfomycin resistance determinant.
The class 1 integrons are genetic elements capable of integrating gene cassettes by a site-specific recombination mechanism (1). Gene cassettes are mobile units composed of a gene, most often an antibiotic resistance gene, and a recombination site, the 59-base element (1). We have previously characterized a class 1 integron containing a VIM-2-type metallo-lactamase gene, blaVIM-2, an aacA4 gene...
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Fosfomycin, [L-(cis)-1, 2-epoxypropyl phosphonic acid] (FOM), a broad spectrum antibiotic produced by some strains of Streptomyces species1), acts as a phosphoenolpyruvate analog and irreversibly inhibits phosphoenolpyruvate UDP-N-acetylglucosamine (UDPG1cNAc)-3-O-enolpyruvyl transferase, an enzyme which catalyzes the first step of peptidoglycan biosynthesis2). FOM enters susceptible bacteria b...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.03131-14